Nids

Trina, here is a citation that doesn't address your question about
how to increase perfusion but may provide clues regarding possible
etiology specific to hippocampal regions and what the SPECT may be
indicating. I can't help but wonder if an immune infiltration headed for the
hippocampus at some point, then the portion of the bbb adjoining the hippocampi
might have been affected in ways leading to hypoperfusion. The following offers
a *possible* etiology, but whether or not the article's information applies to
your son is not known.
The following citation describes how inflammatory response to
intracerebral HSV can damage subcortical structures including the
hippocampus, while sparing the cerebral cortex, including cortical areas
positive for HSV. Furthermore, an entry route from corneal scarification
(scratching the cornea) led to more neuronal damage (from lymphocyte
infiltration) that did intracerebral injection of HSV.
Song GY, Jia W.
The heterogeneity in the immune response and efficiency of viral
dissemination in brain infected with herpes simplex virus type 1 through
peripheral or central route.
Acta Neuropathological 97.649-56 1999
From the abstract:
...we studied the correlation between the dissemination of the virus, the
inflammatory responses and the expression of major histocompatibility
complex (MHC) proteins in rat brain infection with herpes simplex virus
(HSV-1) F strain by either corneal scarification or intracerebral
injection.
Our results showed that the mortality of the corneally infected rats
was much higher than that of the intracerebrally infected rats, due to a
more extensive dissemination of the virus in the brain, particularly in
the brain stem.
The inflammatory responses were similar in brains infected through
either route, as demonstrated by the expression of MHCI/II antigens on
infiltrating lymphocytes, leukocytes and macrophage/microglia cells.
While there was strong immunoreactivity for HSV-1 antigens in the
cerebral cortex, the [immune cell] infiltrates were only located in
subcortical areas, especially the hippocampus.
Therefore, the distribution of these immune cells did not always
overlap with the regions of viral infection.
These results suggest that HSV-1 disseminate more efficiently from
the peripheral to the central nervous system (CNS) than from the CNS to
CNS, which is independent of the immune responses, and that the cerebral
cortex may immunologically respond to HSV-1 infection differently from
other brain regions.
From the article:
[a] "...the inflammatory response [to HSV] may not depend on viral
replication, since infection with a replication-defective mutant virus
could also induce a similar immune response..."
[b] "...in the corneally infected rats...numerous neurons with positive
staining for HSV-1 [monoclonal] antibodies [a lab tool] were located in
the in the sensory cortex... Columns of infected cells through all
cortical layers were occasionally seen... the number of infected neurons
in the brain stem was substantially higher in cornea-scarified than in
cortically injected animals."
[c] Citing Kennedy PGE et al 1983, the authors write: "...cortical
neurons were the least permissive cell types... the difference in the
efficiency of viral dissemination in the brain lies in the distribution
of the receptors on the cytoplasmic membrane of different cells and
terminals. In the cornea scarification model, the virus infected the CNS
retrogradely through the synapses of sensory projecting afferents, while
the intracerebrally injected virus may infect mainly cortical cell bodies
and the synapses of local circuits [other cites]. In has been shown that
attachment of HSV-1 to neuronal cell bodies is much less efficient than
to their terminals [cite]. In addition, specific tropism by HSV for
monoaminergic circuits has also been reported..."
[d] It is clear that [immune cell] infiltrates and MHC class II
expression were restricted to subcortical regions, the hippocampus, and,
to a much lesser extent, the pyriform area. Some of the inflammatory
cells may respond directly to [focal] viral encephalitis, as these
[inflammatory] cells were found immediately surrounding the necrotic
areas shown in the hippocampus..."
[e] "...neurons in the CNS have been reported not to express MHC
molecules [cite] or the espression was only induced by interferon gamma,
which is also neuronal-activity dependent [cites]"
{ for a discussion of MMR vaccination-induced interferon gamma
and its effect on infected cells within the CNS, see:
http://www.jorsm.com/~binstock/mmr-v-g.htm }
[f] "...infiltration of T lymphocytes or other immune cells may
contribute to CNS damage as much as the virus does [cite]. The mismatch
in locations of viral infection and MHC-expressing immune cells in the
present study suggests that an inflammatory response to HSV-1 infection
in the brain may have a range of consequences much broader than
eliminating viral infection..."
<<< On Saturday, July 17, 1999, Trina Montgomery had written:
I am back from California where we took our son to see Dr. Susan Fosnot, Dr.
Goldberg, and had the neuro spec scan. The scan showed that our son has
decreased perfusion to the hippocampus and central white matter of his
brain. Ironically, his temporal lobes did not show decreased perfusion. I
did not have access to the internet while there and just walked in from the
airport. So, who out there can shed some light on this? Goldberg is
adjusting some of our meds and we are going to start some new ideas from
Fosnot. But, are there some over the counter things I can do to increase
the bloodflow to these areas of his brain (MSM, DMG, CoQ10, etc. )? We
already do transdermal secretin and SSRI's.
Trina

Lois,
Glad to hear of JJ's success! How wonderful it must be to see him do things
so independently!
Janie

Trina,
Here is the website for Cognitive Concepts who make Earobics.
http://www.cogcon.com/ The home version is $59. They also have this
number listed on the site for orders: 1-888-328-8199. Mon-Fri from 9-5 CST.
Hope this helps.
Janie

Hi,
Dr. Fosnot recommended the Earobics program and demonstrated it in her
office. I want to order it and wondered if someone had the #. She is
planning to send me the information in a couple of weeks with her report,
but I want to get it ordered ASAP.
Thanks,
Trina

Hi,
I just returned from California where we took our son to see Goldberg,
Fosnot, and to have a neuro spec scan. The scan showed a decreased
perfusion to the hippocampus and central white matter. Can anyone shed more
light on the matter?
Trina

Thank you. It makes perfect sense based on David's grouchy behavior and
desire to do nothing but sit in front of the tv and vegetate. Maybe next
time I will give him Tylenol and see if it helps. What do you do to feel
better?

I'll have to pay more attention to this. I had forgotten about my
daughter's sensitivity to pressure changes. Things got better when she had
tubes in her ears, and much worse when the tubes fell out, but with the
subsequent dairy removal we no longer needed the tubes, and her obvious
reactions to pressure changes are gone. She isn't as good on rainy days,
but I assume it's either molds or the lack of light.
I had a teacher in HS who said the kids always had higher pitched voices on
rainy days.
Mary K.

Hi, All...
I never put two and two together, but since we moved to San Diego a year ago
I havent noticed my 14 year old ( AS ) daughter being as moody.. hmmmmm, I
hardly ever rains here.
We were recently back in NY where we used to live and she was a total grump
some days. Granted it was 101 degrees and HUMID, but it also did rain . I
find this fascinating. I guess moving to San Diego was a good choice for
many reasons.
Also on another thread here was the question about meds. My daughter has been
in the past on Ritalin, which helped greatly with school work, but the
rebound was tough everyday. We have tried Risperdal... that was a disaster as
far as I'm concerned. It only knocked her out and made her gain 10+ pounds in
2 months. (Just what an already "different" teenage girl needs).
She is currently on "Total EFA" Natural essential fatty acids and melatonin
at night. The EFA.s have made a big difference. After trial and error I found
what seems to work for her. We started with "Efalex" but she was allergic to
the thyme oil in it, so I searched out other suplements with the same all so
important GLA's. The teachers at school remarked how much calmer and
able to pay attention and stay on task she was within the first week of the
supplements. The melatonin I give her when shes having a tough time relaxing
or is obsessing about something( very common problem with her ).
All in all I see a different child emerging. Shes for the first time able to
interact with other kids, she is actually a part of the "game" or
activity.... its wonderful to see.
I just thought I would add this to the discussion. It seems to be working for
us.
Dale
(Hi, Marlene. I'm still here. LOL)

Aimee. Thanks for your response. I agree that it seems as if the effect of
the weather is less significant as David improves. He also is allergic to
everything. I would love to hear about what you are doing with Dr. Goldberg
that seems to be helping your child. I spoke to Dr. Goldberg briefly at the
conference and am very interested in adding some of what he uses to my son's
regimen of medication, supplements, etc., Thanks. Margie

FWIW, as a person allergic to various environmental elements, I know that
changes in barometric pressure (especially downward -- which generally
happens when a fast moving storm pops up) can induce sinus headaches. I
think it's due to my sinuses being somewhat swollen from allergens and thus
they don't adjust well to quick changes in air pressure.
Jeff

Hi Cheryl and all,
I'm glad someone mentioned the CFIDS/ME/FMS people having the same ill
reaction to barometric pressure. I'll jump in here too and say that when I
was ill with CFIDS/ME, I did get really ill when a storm came through.
I have always felt that to be due to CELL PERMEABILITY, which is related to
leaky gut syndrome. Always felt like things were getting pulled or pushed
through cell walls that weren't supposed to be there.
Personal opinion that omitting oils from the diet and supplementing EFA's,
essential fatty acids, was what healed that aspect of my illness. Seemed
like it was putting a new sealant coat on all the cells. Imagination,
maybe.
Kathryn
evansc@...

I visited Dr. Fudenberg earlier this year with my son. I believe at one
time he may have been a great help but that time is past. I spent a lot of
money to have him look at pages and pages of forms, many tests, and nothing
ever came of it. He is only a consultant to your regular doctor. Because
of his age, it is difficult to understand him and he talks way over my head
about immune system stuff. I would not recommend him based on my
experience. Tom

I just got home from the CFIDS/Fibro support
group and read your message. Its so strange
because that very subject came up. Everyone was
talking about how they were more irritable when
there were barometric changes and the ones with
Fibromyalgia mentioned more pain. I didn't hear
anyone mention any solutions. But my son seems
to be doing well enough now that I haven't had
any behavior changes with him.
Cheryl

I have heard of hyperbaric chamber treatment helping with this. And yes,
helping autistic kids. Aside from this little bit of info, I am sorry I
cannot be of any more help. Marlene

This is a very weird question, but I thought just MAYBE someone out there is
experiencing this: whenever there are dramatic fluctuations in barometric
pressure, i experience some behavior problems with my autistic son--he gets
very irritable , sometimes hostile, and very non-compliant. People say it's
from being cooped up (like when there's been a lot of rain), but I see no
connection---he gets this way when storm fronts move through quickly , with
no rain making us housebound. At the same time that he becomes a real pill,
I get very spaced out (like super intense PMS, without the irritability).
Does anyone know ANYTHING that can be done to avoid these reactions ?

Hi Listmates!!
Off topic but I have to tell you how proud of JJ I am!! JJ stared
horseback riding last december and when he first stared he had 3 walkers
beside of him. Tonight he want and he RIDES the horse ALONE!! He now
knows how to turn the horse right and left and how to "kick" him to make
him go and listens to directions and takes (OLLIE) to whereever his
teacher want him to go!!! Hes come along way and I just wanted to say
how proud of him I am!! Lois (JJs mom)

<Frustration
sent TF in forms we cannot use.
If anyone can suggest a *reliable* source of TF per subject, I'd be very
grateful.
Mark Lumsden
http://www.ureach.com/mlumsden

Thanks for the info. Jeff. I'll give them a try.!
Diane

According to Patty Baker, you cannot O.D. on transfer factor. Again the
best source of information regarding the use of transfer factor with
autistic kids would be Hugh Fudenberg (864-591-0944) since he's the one who
performed the published study. Patty Baker (800-639-1343) can probably
refer you to a few doctors who have recommended transfer factor to their
autistic patients who could also give you more details about dosaging.
Jeff

"Pacemaker for the Brain" Helps Children with Epilepsy
A new treatment for children with intractable epilepsy involves
implanting a device similar to a cardiac pacemaker to control
seizures. The pediatric vagus nerve stimulator implant program
founded by a Medical College of Wisconsin physician at Children's
Hospital of Wisconsin is one of the few of its kind in the nation.
Children's Hospital is an affiliate of the Medical College of
Wisconsin.
Vagal nerve stimulation (VNS) sends timed electrical pulses to the
brain through the left vagus nerve in the neck. This reduces
seizures in epilepsy sufferers for whom there previously was no
treatment.
VNS is not a cure, but rather a way to manage symptoms. It is not
effective in all patients, but when it works, results are
dramatic. Children plagued by constant "drop attacks" may become
virtually seizure-free. The technology even allows some patients
to, in effect, turn off seizures by activating the stimulator with
a magnet.
Dr. Angus Wilfong founded the VNS program at Children's Hospital
in 1998. He is a visiting assistant professor of neurology at the
Medical College of Wisconsin.
For more information or to set up an appointment, please call 414-
456-4090.

All very true, but in the case of our kids, we discovered after testing that
those foods our kids were rejecting or even throwing up were in fact foods
for which our kids had sensitivities or allergies. Why wouldn't they eat
pizza? Because both had strong dairy sensitivies and the cheese made them
sick. Nobody should rule out the possibility that a child's dietary habits
in fact may be trying to tell us something. John

Both my son (developmentaly delayed/speech delayed with symptoms of austism)
and myself (Crohn's Disease) have tried transfer factor. We originally
tried Colostrum (first milk from a cow) but it gave me a terrible headache on
the second day. Transfer Factor is supposedly colostrum with the milk
allergens removed. At first the transfer factor gave me energy and seemed to
help heal my intestine and my son seemed to have less tantrums. I found that
the results wore off after a couple of months. That's our experience.
Diana (Isaac's mom)

Lois,
I looked this company up on the web. I did not find any information
pertaining to autism, althought I did not spend a large amount of
time searching. I DID find that this item is sold through a
Multi-Level-Marketing (MLM) program.
Best wishes,
Sandy

Hello,
Last week my husband and I spent lots of time perusing Dr. Goldberg's
lecture which features SpecScans of numerous children and details their
progress as they respond to treatment. We were very impressed. I was
especially impressed by Dr. Goldberg's unfailing attention to the
importance of education and meaningful activity in the children's lives
as well as to his recommendation that we pay attention to what the kids
say. About themselves especially. Also, to the idea that frequently
the children may suffer pain from things like swelling of the brain.
Here is my question today:
Our son John is 26. Because his health has been very uneven and because
his method of communication has been almost universally rejected (FC),
he does not go to any day program. So when he is up and about, Papa and
I are the program. Today we visited the grocery, and just like always,
our son RUSHED through the aisles selecting his favorite items non-stop;
he shows almost no impulse control and will *not* be deterred from
having his favorite treat. He moves with kind of a lurching motion, not
at all smooth.
When he was a little guy, our neurologist was Dr. Coleman. She would
tell me that the inhibitory system in our son's brain was not working.
Once she gave us the drug deaner. For several days, the inhibitory
system DID work. Our son was almost 100 percent normal. He went to bed
at normal hours. One night he surprised a friend who was baby sitting
for us by reaching up to turn off his bed room light and tucking himself
in with Teddy the Bear at nine pm. He was about five years old.
Sadly, this deaner honeymoon did not last very long, and next to a three
month period of bliss last summer with low dose prozac, we have never
experienced anything quite like this. Last summer he went horse back
riding and we took in several movies, visited with friends, etc.
Barring infection which alters brain chemistry and which we are
currently investigating, is there any other explanation for the
impulsivity which characterizes so many of our children - at all ages?
And yes, it is worse when folks stare or comment rudely.
Hopefully, we will soon begin again to work on speech therapy. Would
love to know if Dr Susan Fosnot has any good buddies in the Dallas area.
Hoping to learn some good things -
Cornelia Moisuk

Hi everyone!!
I have been off the list the last 3 days boy do I have a lot to
catch up on!!!! I want to get JJ some rice spgetti at the health food
store and the man there gave me an article on "transfer factor" Has
anyone heard of it?? its suppose to be a natural immune booster. Its
from 4life Research. It is suppose to help with autism. they did a pilot
study on 22 autistic children and said that 21 responded to the
treatment!! And 10 of the children was able to enter mainstream schools.
Please let me know if any of you have used it or know of it
Lois (JJs mom)

Etiology of measles- and rubella-like illnesses in measles, mumps, and
rubella-vaccinated children.
Davidkin I, Valle M, Peltola H, Hovi T, Paunio M, Roivainen M, Linnavuori K,
Jokinen S, Leinikki P
J Infect Dis 1998 Dec;178(6):1567-70
National Public Health Institute, Helsinki University Central Hospital,Helsinki,
Finland. Irja.Davidkin@...
The viral etiology of measles- or rubella-like illnesses after MMR (measles,
mumps, and rubella) vaccination was studied prospectively in 993 acutely ill
Finnish children with fever and rash in 1983-1995. Their sera were tested for
adeno-, entero-, and parvovirus B19 antibodies. Sera of 300 children <4 years
old were also tested for human herpesvirus 6 (HHV-6) antibodies. Measles and
rubella had been excluded by previous antibody testing. Serologic diagnosis of
adeno-, entero-, or parvovirus infection was based on EIA (IgM or IgG
antibodies) and that of HHV-6 on indirect immunofluorescence. A viral etiology
was verified in 368 cases, most commonly parvovirus (20%), followed by
enterovirus (9%) and adenovirus (4%). Among young children, HHV-6 infection was
found in 37 (12%). Thirty-eight children (4%) had double infections. This study
confirms that measles- or rubella-like illnesses in MMR-vaccinated children are
often caused by other viruses. Each suspected vaccine failure requires
laboratory confirmation to maintain reliable surveillance and control and to
establish the specific etiology of the disease.
PMID: 9815205, UI: 99034637

Michelle,
The fundraising proposal I sent you represents a major corporate sponsorship
for your ARK work - without added expense. It boils down to every person in
your network bringing in a minimum of $30 per head in the next 60 days.
Have you had a chance to look over the file I sent you? I know there is a
sense of urgency in raising money for this rally and it seems a good fit.
I'm willing to help in any way I can.
Michelle Bufkin
214-443-0067

Hello all,
If you have sent me your donation letter list to do for you, I will do it
this week now that I have the remittance envelopes to complete the project.
Thank you for being patient with the delay's I have had with the printing.
I have had some personal issues come up, and now am at the point that I can
focus on the ARK mailout mission. If I can assist you in any way regarding
mailouts and donation letters and information, please let me know.
Eric and everyone who had the same question on the list:
OUR MAIN FOCUS RIGHT NOW THROUGH OCTOBER IS GETTING THE WORD OUT ABOUT ARK
AND THE "HEAR~THEIR~SILENCE" RALLY FOR AUTISM AWARENESS ON APRIL 8, 2000.
WE NEED FLYERS OUT, DONATION LETTERS MAILED, CORPORATIONS AND AUTISM RELATED
GROUPS CONTACTED; AND DONATION LETTERS MAILED OUT TO THEM. GET ME YOUR LIST
TO DO FOR YOU, OR CONTACT ME TO GET YOU THE MATERIALS YOU NEED TO DO IT.
REMEMBER TO INCLUDE A DONATION REMITTANCE ENVELOPE IN ALL DONATION LETTERS
MAILED OUT!!! INCLUDE A RIBBON AND AN ARK BUSINESS CARD TOO!!!
WE NEED CORPORATE SPONSORS!
Thank you for all your help for ARK!!!
Michelle Guppy

http://www.house.gov/reform/cj/hearings/5.18.99/Dunbar.htm

Hello all!
I HAVE 1500 ARK DONATION REMITTANCE ENVELOPES ON MY DESK - F-I-N-A-L-L-Y!!!!
YOU NEED TO REQUEST TO ME WITH NAME AND ADDRESS HOW MANY FOR ME TO MAIL OUT
TO YOU TO STUFF IN YOUR DONATION LETTERS WE ARE ALL MAILING OUT!!!!!
MY APOLOGIES THAT IT TOOK SO LONG, BUT THEY ARE HERE NOW AND READY TO SHIP
OUT TO YOU. THEY WILL BE STAMPED, SO PLEASE BE SURE AND INCLUDE THEM IN
YOUR DONATION LETTERS!!
THANK YOU ALL SO MUCH FOR THE COLLECTIVE EFFORT IN GETTING THIS HUGE MAILOUT
TASK ACCOMPLISHED WITH THE SOLE PURPOSE OF RAISING MONEY TO GET TO THE
"HEAR~THEIR~SILENCE" RALLY FOR AUTISM AWARENESS APRIL 8,
2000!!!!!!!!!!!!!!!!!!!!!!!
WE HAVE TO HAVE ALL DONATION LETTERS SENT AND CORPORATIONS CONTACTED BEFORE
OCTOBER 31ST!!!! WE HAVE TO HAVE THAT DEADLINE BEFORE THE HOLIDAY SEASON
AND SLOW BUSINESS AND HOLIDAY EXPENSES. WE NEED TO GET THE DONATIONS IN
NOW!!!!!! AM I BEGGING LOUD ENOUGH?? HA HA HA
THINK WASHINGTON!!!!!!!
THINK CORPORATE SPONSORS!!!!!!
THINK AUTISM AWARENESS!!!!!
THINK RESEARCH MONEY!!!!
THANK YOU EACH OF YOU FOR ALL YOUR SUPPORT AND CONTRIBUTIONS!!!! WE ALL
WILL MAKE A DIFFERENCE!! WE ARE MAKING A DIFFERENCE!!
MICHELLE
I will get the business card file posted so you can include a business card
in your mailouts. I am computer illiterate and am hounding my computer half
to get the job done!! It will be posted this week!!!!
Michelle

"Cerebrospinal fluid from two non-neurologic IM patients had neither
EBV DNA nor EBV antibodies." However, EBV was found in CSF samples
from 5 EBV+ children who had neurologic symptoms. Atypically elevated
EBV titres in autism-spectrum children may be a significant clue.
Articles such as this provide a foundation for requesting that medical
insurance pay for further testing and treatment of such children.
Teresa
J Med Virol 1993 Aug;40(4):278-84
Epstein-Barr virus genomic sequences and specific antibodies in
cerebrospinal fluid in children with neurologic complications of acute
and reactivated EBV infections.
Imai S et al.
Department of Virology, Hokkaido University
School of Medicine, Sappord, Japan.
Four children with infectious mononucleosis (IM) and one with
reactivated Epstein-Barr virus (EBV) infection had concomitant central
nervous system disorders. Cerebrospinal fluid (CSF) samples from all
five patients contained EBV genomic sequences and EBV-specific
antibodies in the neurologic stage, but not during convalescence.
Cerebrospinal fluid from two non-neurologic IM patients had neither
EBV DNA nor EBV antibodies. The EBV-positive CSF of the five with
neurological disorders were aseptic in culture and all negative for
other human herpesvirus DNAs and antibodies: herpes simplex virus
types 1 and 2, cytomegalovirus, varicella-zoster virus, and human
herpesvirus 6. Epstein-Barr virus DNA and EBV antibodies were not
detected in the CSF of 17 EBV-seropositive patients with mumps
meningitis, rubella encephalitis, unknown febrile convulsion, or
partial epilepsy. It is suggested that EBV plays a causal role in
neurologic manifestations in patients with acute and reactivated EBV
infections, through direct viral invasion and immunopathological
reactions.
PMID: 8228918, UI: 94045566

The following appears on a webpage (link hereinbelow) and does mention that
Valtrex is "partially inhibitory" towards HHV6 replication. This particular
quote does not mention Valtrex effectiveness in regard to the various HHV6
strains.
And a thnx! to the Parent who forwarded the link.
Teresa
Acyclovir (ZOVIRAX)
Currently available data indicate that HHV-6 is relatively insensitive to the
inhibitory effects of acyclovir. The mean inhibitory concentration 50% (IC50)
of acyclovir for HHV-6 strains is approximately 30 uM, a concentration well
above the plasma levels achievable with either oral or intravenous therapy with
ZOVIRAX.
Acyclovir (VALTREX)
A new prodrug (converted to acyclovir by the liver after ingestion),
valacyclovir or VALTREX, can produce blood levels of acyclovir that are much
higher than those obtainable with ZOVIRAX, and these levels may be at least
partially inhibitory toward HHV-6 replication. Used at a oral (by mouth) dosage
of 1 gram three times per day, valacyclovir can achieve plasma concentrations
of acyclovir of approximately 22 uM (4.9 micrograms per milliliter). This level
of acyclovir would be partially effective against HHV-6. Oral administration of
VALTREX has been shown to decrease the incidence of HHV-6 associated disease in
bone marrow transplant recipients. Also, studies have demonstrated that VALTREX
therapy at standard dosages is associated with a low rate of adverse side
effects. Thus, VALTREX treatment stands as a potential alternative for
long-term therapy for HHV-6 associated diseases, especially in combination with
another antiviral drug such as beta interferon.
http://www.hhv6.com/drugs.html

A measles-vaccine non-responder is more likely to acquire other
infectious diseases (1).
A persistent elevation in anti-measles titres can mean that a child
has a specific HLA gene (HLA-DRB1*13) associated with
hyper-responsiveness to measles vaccination (1).
"The absence of HLA-DRB1*13 alleles is associated with measles vaccine
nonresponse. The absence of this allele has also been associated with
susceptibility to other infectious diseases." (1)
Teresa
1. Hayney MS, Poland GA, Jacobson RM, Schaid DJ, Lipsky JJ
The influence of the HLA-DRB1*13 allele on measles vaccine response.
J Investig Med 1996 Jun;44(5):261-3.
Mayo Vaccine Research Group, Clinical Pharmacology Unit,
Mayo Clinic and Foundation, Rochester, MN 55905, USA.
BACKGROUND: Measles remains a public health threat in the United
States with over 50,000 cases being reported from 1989 through 1991
with continued smaller outbreaks. Measles vaccine failure is in part
to blame for these large-scale outbreaks. The human leukocyte antigen
(HLA) genes are important determinants of immune response to measles
virus and vaccine. To examine the influence that HLA polymorphisms may
have on measles vaccine antibody response, we compared the
distribution of HLA-DRB1 alleles between measles vaccine nonresponders
and hyper-responders.
METHODS: We determined the seroprevalence of measles antibody in 881
school children immunized with measles-mumps-rubella-II at age 15
months using a whole virus IgG EIA. We performed class II HLA-DR
typing by PCR with sequence specific primers (PCR-SSP) on 81
nonresponders (IgG seronegative) and 65 hyper-responders (from the
upper 10th percentile of IgG levels of all subjects). We then compared
the distribution of alleles between nonresponders and
hyper-responders.
RESULTS: The distribution of HLA-DRB1 alleles among nonresponders
compared to hyper-responders was significantly different (p = 0.014).
Nonresponders were significantly less likely to carry the HLA-DRB1*13
alleles than were hyper-responders (7.4% vs 16.2%;p = 0.02).
Nonresponders also had an excess of HLA-DRB1*07 alleles (15.4% vs
6.2%; p = 0.015).
CONCLUSIONS: The absence of HLA-DRB1*13 alleles is associated with
measles vaccine nonresponse. The absence of this allele has also been
associated with susceptibility to other infectious diseases. The role
of this gene in the immunogenetic response to infectious diseases
requires further study.
PMID: 8763977, UI: 96321546

The following article illustrates a principle and does not mean that any
specific autisms-spectrum child has the antibodies pattern described by
Karpas and colleagues, who wrote:
"...a deficiency in the cell mediated immune response to the
persistent viruses might be the reason for the abnormally high
antibody levels." (1).
This principle has been increasingly documented in recent years, augmented by
the newer
lab techniques such as PCR.
In some autism-spectrum kids, one of their immune impairments is that of
forming no antibodies against a specific pathogen (or its vaccinal
antigen). Such pathogen-specific impairments of immunity seem an important
clue in *some* autism spectrum children, because pathogen-specific immune
impairments can lead to chronic infection not fully immunosuppressed. Two
examples illustrate impaired antibody responses as a different type
of immune glitch (2-3).
Teresa
1. Br J Haematol 1980 Jun;45(2):195-200
Sinus histiocytosis with massive lymphadenopathy: virological,
immunological and morphological studies.
Karpas A, Worman C, Arno J, Nagington J
The histiocytes from a patient with sinus histiocytosis were tested for
the presence of Epstein-Barr viral nuclear antigen (EBNA) before and after
in vitro growth. On both occasions the histiocytes as well as the
lymphocytes were EBNA negative. Likewise the profile of EBV viral capsid
antibody (VCA) suggests that this virus is unlikely to be directly
involved in the development of the disease. The maintenance of an
unusually high level of antibodies to EBV and measles, both viruses which
produce persistent infections, indicates that the humoral immune response
is active. That a normal humoral response occurred in response to mumps
virus during the same period suggests that a deficiency in the cell
mediated immune response to the persistent viruses might be the reason for
the abnormally high antibody levels. The fresh as well as the cultured
histiocytes had only Fc receptors. The affected lymph node lymphocytes
developed unusual large inclusion bodies following in vitro culture.
PMID: 6254557, UI: 81063054
2. Cancer 1979 Apr;43(4):1375-9
Possible role of mumps virus in the etiology of ovarian cancer.
Menczer J, Modan M, Ranon L, Golan A
Eighty-four ovarian cancer (OCa) patients and 84 controls with
nonmalignant conditions matched by age and ethnic origin were interviewed
with regard to clinical mumps history and their sera were tested for
complement fixation (CF) mumps antibodies. OCa patients differed from the
controls in the response to past mumps infection in two respects: 1) They
appeared to be more likely to have developed subclinical mumps as
evidenced by a lower rate of clinical mumps history in the presence of
serological evidence of similar infection rates among those with positive
and those with negative clinical mumps history. 2) They tended to present
lower persistent mumps CF antibody titers. These results may be
interpreted to indicate that an immunological incompetence enables the
development of OCa possibly through a direct etiologic role of mumps
virus.
PMID: 445337, UI: 79189265
3. Andrologia 1977 Jul-Sep;9(3):207-15
Immunological studies in patients with mumps orchitis.
Andrada JA, von der Walde F, Hoschoian JC, Comini E, Mancini E
Seventy patients with mumps orchitis were investigated. Serological tests
for antitesticular antibodies, using four different techniques showed
positive results in 25 patients. Antivirus antibodies were detected and
they reached higher values during the remission period of acute cases.
Delayed hypersensitivity was studied by means of skin tests using
homologous antigenic material. Several patients gave definite positive
reactions. Testicular biopsies performed in some patients showed a
histological picture similar to that obtained in experimental human or
animal auto- or iso-sensitization. All patients in whom testicular damage
was present also showed positive skin tests, ascertained by histology of
the site of reaction, but none of them exhibited circulating antibodies in
meaningful titers. The skin hypersensitivity suggest some correlation
between this type of reaction and the development of the testicular
lesions as shown in several other diseases in which an immune mechanism
could be involved.
PMID: 907207, UI: 78018177

Can you please put me back on the regular email list and take me off of
digest? thanks. Margie Knight

Infect Immun 1984 Mar;43(3):1041-6
Two mechanisms of inhibition of human lymphocyte proliferation by soluble yeast
mannan polysaccharide.
Nelson RD, Herron MJ, McCormack RT, Gehrz RC
The literature on chronic mucocutaneous candidiasis contains multiple reports
which suggest that loss of cell-mediated immunity in this disease may be related
in part to the presence of an inhibitory factor(s) present in patient plasma.
One such inhibitory factor has been suggested to be mannan polysaccharide
released from the cell wall of the pathogen. The present report describes
results of experiments to consider mechanisms by which yeast mannan influences
proliferative responses of human lymphocytes. Mannan for these experiments was
isolated from Saccharomyces cerevisiae. We observed that mannan-mediated
inhibition of proliferative responses to a battery of stimuli
(phytohemagglutinin, pokeweed mitogen, and Candida, mumps, streptococcus,
cytomegalovirus, and herpes simplex virus antigens) was related in part to an
effect of copper associated with the mannan and possibly to the superoxide
dismutase activity of the mannan-copper complex. Mannan made deficient in copper
by use of a copper-chelating resin appeared to inhibit only lymphoproliferation
stimulated by the Candida antigen. These results suggest that inhibitory effects
of yeast mannans on lymphoproliferative responses may involve at least two
mechanisms, one related to hydrogen peroxide production augmented by
mannan-copper complexes and another related to still unknown effects independent
of the metal ligand. We propose that our results represent a significant novel
observation which may be useful in understanding mechanisms of immunoinhibitory
effects of C. albicans mannan.
PMID: 6365780, UI: 84134404

Hello,
I would like to invite you to join the autism_marriage mailing list.
The description of this mailing list is:
Being the parents of an autistic child in the '90s takes a very heavy toll on
the vitality and even the very survival of many couples' relationships. This
list is for parents, and interested counselors and other helping professionals,
to discuss what these strains are and how to try to cope with them.
You can join this list by going to the following web page:
http://www.onelist.com/subscribe.cgi/autism_marriage
If you do not wish to join this list, please ignore this message.
Thanks,
marklumsden@...
List Owner

There is a very important bill that I have been
keeping tabs on.
For those of you in Calif. AB1207 would establish
the Healthy Schools Act of 1999.
The Legislature finds and declares all of the
following:
(a)A significant but unknown number of schools
present environmental hazards to children and
school staff as a result of poor indoor air
quality,pesticide exposure,and other environmental
deficiencies.
(b)The protection of our children's health demands
a precautionary approach when regulating toxic
chemicals in schools. In the face of potentially
significant but unmeasurable health risk, exposure
should be avoided or minimized until they are
proven to be safe.
(c)Temporary or portable classrooms may expose
school children to unacceptable levels of toxic
chemicals that increase the risk of asthma,cancer,
and other serious illnesses, though these risks
remain inadequately studied.
The next action on this bill is set for 7/12.
It will among other things, prohibit the use
of pesticides known to cause cancer or
reproductive harm,contain an active ingredient
identified as a known or probable carcinogen,class
I pesticides,class II and are ORGANOPHOSPHATE or
n-methyl-carbamate nerve toxins.
To see the full bill go to
www.assembly.ca.gov
click on Legislation
go to AB1207
Cheryl

Thank you!
Kathryn

I'm not aware of any research on prions, but there
is alot re: pesticides and immune and nervous
system damage.
There is an article that was published in Good
Housekeeping regarding pesticides and damage to
the lungs,immune and nervous systems. It has a
quote from Carol M. Browner, Administrator of the
U.S. EPA re:pesticides. She doesn't use any in
her home or yard because of the risks to her son.
http://homearts.com/gh/betterw/1096sab1.htm
another good site with studies on health effects
sample-Pesticides in homes and lawns linked to
serious long term immune and neurological problems
http://www.chem-tox.com
Cheryl

Let's close the loop!
Does anyone know of research showing that organophosphates (pesticides in
general) cause the mutation of normal proteins into prions? Both
organophosphates and prions play a role in BSE, and I assume in NIDS:
CFIDS/ME; autism; Alzheimer's.
Kathryn Evans
evansc@...

Michelle,
I received your flyers. Have you reviewed the fundraising plan I sent you?
Michelle

Alexis and all,
The ARK is moving forward to the rally!!! THE MOST IMPORTANT ISSUE AND TASK
AT HAND IS DONATIONS!!! WE NEED MONEY TO GET TO D.C. TO PAY FOR ALL
EXPENSES INVOLVED IN THE MAKING OF A RALLY!!!! EVERYONE MUST SEND OUT
DONATION LETTERS TO BUSINESSES, CORPORATIONS, FAMILY, FRIENDS, NEWSPAPERS,
MAGAZINES, ANYWHERE TO HELP GET THE WORD OUT ABOUT US!!! WE WANT THOUSANDS
OF FAMILIES AND PEOPLE AT THE RALLY - - - SO WE NEED TO GET THE WORD OUT!!!
I am your contact person for anything regarding getting the word out through
mail. I can E-mail you the file to print your own. I need to know how many
donation envelopes you need to include in your letter. Send me your E-mail,
and mailing address.
We need to set a goal to have every contact contacted by October 31st.
Every donation letter and flyer needs to be passed out and mailed by October
31st. We need to get that done before the rush of the holiday season sneaks
up, and kids get busy with school, and what little time we have is lost at
that point!! I know I don't have much free time at the holidays and once
school starts!! SO PLEASE, I BEG OF YOU ALL TO MAKE A PERSONAL DEADLINE OF
OCTOBER TO GET ALL YOUR DONATION LETTERS OUT, ALL PEOPLE YOU CAN THINK
OF!!!!! Write to every newspaper you have in your area!! Type up a story
about how Autism has affected your family, and about the need for Awareness,
and just mail it to every column writer in the newspapers. SOMEONE WILL
READ IT AND DO A STORY!!!! BE PERSISTENT!!!
I have received several people's donation lists - I have not forgot, I have
been waiting for the remittance/donation envelopes to be printed up. They
are ready, so I can get to work.
Anyway, that is the urgent need at this point. We have people working on
T-shirts, Permits, D.C. technicalities - Joanne, A PR person - Roz,
Fundraising cookbook and speakers - Steph, the donation committee - all of
you!!!!
Hope that answers your questions, PLEASE CONTACT ME FOR DONATION
INFORMATION!! I WILL GET YOU ANYTHING YOU NEED!!
:-))))
Michelle Guppy
16210 Cypress Trace
Cypress, TX 77429
tguppy@...
281-304-0371

Sandy,
I had no idea Thimerosal was in some vaccines or
that it is an organic form of mercury. What I do
know is that when I was a teen I found out that
I am very allergic to it. When I wore contacts,
I would get a severe infection in both eyes if
thimerosal was in the solutions. I also had a
bad experience when I had a make-up session and
my eyes became severely infected, after checking
with the manufacturer I found that thimerosal was
in the mascara.
Cheryl

Quote: "WASHINGTON (AP) -- The government is about to
ask manufacturers to remove from vaccines a type of mercury used
as a preservative since the 1940s, citing concern that small infants
now need so many immunizations that they may get too much of the
chemical, The Associated Press has learned."
The entire story may be found at:
http://www.newsday.com/ap/rnmphs0b.htm

Marlene,
I understand your frustration with the school.
Everyone has understood that my son had a medical
problem, except the school psychologist was having
a hard time accepting the whole picture. It took
having a letter from a psychiatrist who said that
my son had an autoimmune problem that could cause
.... for him to finally say, now that makes sense.
I couldn't believe it. All the other info I had
given had said essentially the same thing. I
guess for him he needed something from someone
who works with mental health.
Cheryl

Hallo, I'm Gloria from Italy,
I would like to know what tests I should ask my son's physician, to determine if
there is an immune disorder probably linked to a vaccination. In that case I
think it was the hepatitis B vacc.
I have already had these tests done:
HLA:
HLA-DRB1* 11,1303
HLA-DRB3*
HLA-DRB4* DRB3*02
HLA-DRB5
Locus A A26, A28
Locus B B14, B49 BW4, BW6
LocusC CW7
Then the tests from Dr. Singh:
Myelin Basic Protein (MBP) Antibody...........Positive
Neuron- Axon Filament Protein (NAFP) Antibody.......Negative
Measles Virus Antibody (MV-IgG).......335 Units(positive)
What else should I do?
Thank you
Gloria

As focused on in my earlier responses about Secretin and the MMR, etc., my
recent posting "these are children" (see posting www.neuroimmunedr.com ) and
in turn looking upon these children as a Pediatrician, it is becoming
obvious that most / all of what happens is "logical," as per any other
pediatric patient. In this case, the frantic frustration, watching an " out
of control" child become more out of control say two important points
1. As noted appropriately by other parents, IF NOT working successfully,
regroup, rethink what is happening, it is generally not going to be right or
you are "missing" some other factor.
2. Treating just symptoms (i.e hyperness, aggression, distractability) may
be an enlarging disservice to a child who may be "wired" on various foods,
additives, or meds, who may have severe "headaches" or "brain swelling"
symptoms secondary to the idea of a "meningoencephalitis" type process, body
aches, etc.
IF a physician or "expert" prescribing a medication or treatment plan does
not have a good Pediatric orientation, a good understanding of the
likelihood that your child was at one time was normal, not born "miswired or
injured or genetically altered" then they do not likely understand what they
are trying to accomplish with their medications or treatment plans. IF
viewed as children, there is no place for many of the treatment approaches
(or attitudes) being supported out there.
NONE of these children should be left suffering any longer than necessary.
The distress expressed here as parents, I hear echoed daily. We must turn
to new routes, newer understandings rapidly, or we will not only continue to
mistreat many children, we will ultimately loose our future "leaders" of
tomorrow (look at the enlarging connection supporting "productive" families,
professionals, higher IQ families, etc.).
Let's make this change - it can now be done
Michael Goldberg, MD
Message: 11
Date: Tue, 22 Jun 1999 19:18:26 EDT
From: Lizanj@...
Subject: Re: HELP!!!!
Betty,
maybe you missed my post re what happened; Jamie was diagnosed as
having an inner-ear infection as well as a throat infection, he's unable to
speak, but usually able to communicate what he wants....will go and get
whatever it is/take me to it....he's very hyperactive and we've been unable
to get much 'academia' from him....but he is a fighter and is extremely
assertive!!!! (he hits/scratches/bites me if I pick up the 'phone....does
this also to anyone he identifies as 'primary carer'....he's gotten a little
bit too used to having one-to-one 'therapy' and is used to getting his own
way)....I have tried my best...but haven't done a thing different than any
other parent would....thanks anyway....all the best..Liz.

Teresa,
What do you mean by anti-CMV antibodies? I have enough immuno background to
understand what CMV antibodies are , and that the antigen is the CMV
itself--but am confused by the above term you use. Do our bodies form
antibodies to the CMV antibodies?
Thanks,
Kate

As illustrated by the ongoing discussion and postings, we are all just
beginning to get the "truth" about Secretin. Time however seems to be
pushing toward:
1. I do not hear any sources other than a DANN doctors or Dr. Rimland,
believing there is any high probability of success with Secretin
* * Rather, researchers who have tried it are not pursuing it, and / or
studies are beginning to come out of true "trials" which are very unlikely
to show any significant success with Secretin
2. Discussion of potential dangers continues to increase
* * The dangers of possibly triggering a negative / destructive auto-immune
reaction in the body is becoming of greater concern, a child could collapse
/ die on the table from an "anaphylactoid" reaction - a very high risk, the
risk of unknown viral or "sub" viral organism being transmitted is very
high, pushing multiple "wrong" rather than "right" pathways / hormones,
remains an unknown concern.
* * No parent should be offered a Secretin "transfusion" for their child not
properly IRB approved, or at minimum having been offered and signed an
"informed" consent listing the above risks.
3. And unfortunately, as with the MMR "assumptions," grains of truth or
hope, continue to deceive this "internet" generation of parents and
children.
IF one backsteps to the direction that "these are children" (please see
posting on website www.neuroimmunedr.com ), then not only does the urgency
of finding an answer increase alarmingly, but then, as it should be, one
must carefully weight risk versus gain, and cannot just "experiment" on a
potentially "devastated" family and child. As I have been discussing, it
has become obvious that many / most of these children must start off
healthy, potentially bright children (just as many parents have believed),
and must be thought of potentially treatable, rather than being born
congenitally damaged or "miswired"
With the NIDS conference creating a chance to focus a new level of science,
potential new therapies for these children rapidly (obtain tapes from the
NIDS conference as soon as available), comes the right to say, these
children must regarded in an "accelerated" model of a medical crisis, but
should only be "exposed" to agents with a high probability of safety and
efficacy, not "unknown" risks, very low probability of gains.
Unfortunately, while suddenly very possible, IF we are to have any chance of
getting these agents to children in the near future, then we are only going
to achieve that by "focusing" parents and groups frustrations and urgency
into a "constructive" grass roots effort (so far no established group is
helping to lead this direction), not diffuse "in" fighting, many "side"
battles, etc. Example: While certainly the MMR may be a "trigger" in some
of the children, science says very strongly it is unlikely to be the cause
of this dysfunction in any significant number. IF one focuses on the
"trigger" concept and the "autoimmune" pathway, there is NO scientific
article that can dispute that possibility. IF one focuses on the idea of
causation, especially implying active measles virus, this leads to great
scientific debate and arguments, because it is not logical. This makes its
easier to throw up scientific arguments / roadblocks, creating more
"studies" (great for the study centers) but not a focus on solving the
problem, creating a solution now. As has been shown time after time, ONLY
scientifically logical (potentially unproven, but NOT disproven) pathways
are going to remain around. This is why a new "cure" comes every 4 - 5
years - frustrating parents and "cheating" these children. We have one shot
now while many of these current children are still young, we all had better
pick the right route.
While it would be nice to sit back and say "wait and see" (ala Dr. Rimland),
and while I do hope parents will begin holding their leader and researchers
accountable for "theories and hypothesis" they may propose (please note who
were proposing "Gamma Globulin" as the wonder drug a few years ago, now
there are increasing stories of kidney damage, along with the ongoing issues
of unknown "transmissions"), we are at a "crisis" point. UNLESS we can all
focus logically, scientifically, and on a definable objective pathway and
markers (via NIDS), unless we create an immediate scientific pathway to
understand these children's variables (not one open to ongoing debate and
subjective assessment) so that we can "understand" objectively results, any
dramatic change in therapy remain many years away.
As reflected by the last posting, there is a common denominator affecting
many of these disorders. In stead of focusing on each small piece of
science, there is a chance, looking to the "big picture" to really make a
difference for many children and their families now. Please review the NIDS
conference tapes (become involved with "MAT for NIDS"), be exposed to a side
and level of science previously denied you and your children, and then
decide if your children are better served waiting 7 - 10 years (for the
existing research networks to "catch-up" - which is starting to happen) or
can we truly utilize the promise of technology and the internet
appropriately / constructively, and have new trials in place for many of
these children by the new millenium.
With hope for many of your children,
Michael Goldberg, MD
Message: 1
Date: Wed, 23 Jun 1999 10:47:39 EDT
From: Wutsername@...
Subject: Re: Physician Responds to Secretin Study Report
<<Date: Tue, 22 Jun 1999 16:38:58 EDT
From: Kkscharste@...
Subject: Re: Physician Responds to Secretin Study Report
Question for Dr. Layton: Are you also doing GF/DF diet with your patients,
as well as treating them for yeast overgrowth, during your trials of
secretin? And if so, perhaps the positive changes you are seeing are due to
these other therapies. Thank you.
I am not Dr. Layton, but I am a parent using secretin to help my autistic
son, and I would like to comment on the question above. My son is GF//DF
and had been for a year prior to his first secretin infusion. Up to that
point the diet had helped him a great deal, but there is NO MISTAKING the
benefits he received from secretin. He took a HUGE leap in
receptive/expressive language, eye contact, appropriate social conduct,
symbolic/imaginative play, the rate at which he learns new things, and his
overall interest in the world around him. He had two infusions and both
brought wonderful results, which he has maintained as is now getting
secretin transdermally. He was not being treated for yeast overgrowth or
anything else at the time he received his infusions.
Kind regards,
Ricci Carole Hedequist
List moderator, secretin-discussion@egroups.com

Anti-CMV antibodies levels can be difficult to interpret because early
exposure to CMV can lead to an impaired Ig response against CMV 1-2). In
fact, some individuals have no antibodies despite having documented
presence of CMV (3).
Thus, if a child's anti-CMV antibodies levels are within the normal
reference range or are reported as not-detected, that fact does not rule
out that his or her CMV can be excluded as pathogically significant in
various ways.
If (a) a child's medical history is consistent with CMV-related traits,
and (b) his or her anti-CMV antibodies levels are within normal range,
then PCR of polymorphonuclear leukocytes is one way to determine whether
or not CMV is present in that individual (3).
Teresa
1. Pass RF et al. Specific lymphocyte blastogenic responses in children
with cytomegalovirus and herpes simplex virus infections acquired early in
infancy.
Infect Immun 1981 Oct;34(1):166-70.
Cell-mediated immune responses in 27 infants and children with
cytomegalovirus (CMV) infection acquired between birth and 1 year of age
were compared with responses in 13 children who had neonatal herpes
simplex virus (HSV) infection. Infection was asymptomatic in 25 of 27
CMV-infected children; the 13 patients with HSV infection were all ill as
newborns. The median age when studied was 46 months for children infected
with CMV and 24 months for those infected with HSV. We measured lymphocyte
transformation responses (LTRs) to CMV antigens in the former group and to
HSV type 1 (HSV-1) (and in six cases to HSV-2) in the latter group, with
the results expressed as a stimulation index. Based on the results in
seropositive and seronegative adult control subjects, stimulation indexes
of greater than or equal to 3 were considered indicative of a positive
LTR. Among the CMV-infected children, a positive LTR was observed in 0 to
13 assays performed before 1 year of age, 3 of 8 assays performed between
1 and 4 years of age, and 9 of 15 assays performed over 4 years of age. In
contrast, a positive LTR to HSV-1 was seen in 15 to 18 assays performed in
children under 1 year of age and in 14 of 16 assays performed in survivors
of neonatal HSV infection older than 1 year. Six HSV-2-infected patients
were tested simultaneously 13 times with HSV-1 and HSV-2 antigens. Those
patients under 6 months of age responded similarly to each antigen,
whereas those who were older had significantly higher LTRs to HSV-2.
Children with CMV infection that was acquired early had persistently
diminished specific LTRs. In contrast, after neonatal HSV infection, LTRs
to HSV were present even in infancy and became more specific for the
infecting type with increasing age.
PMID: 6271679, UI: 82052026
2. Zawilinska B et al. [Congenital and acquired cytomegalovirus infection
in infants confirmed by virologic studies]. [Article in Polish] Przegl Lek
1995;52(7):354-7.
Zakladu Wirusologii, Instytutu Mikrobiologii, Collegium
Medicum, Uniwersytetu Jagiellonskiego w Krakowie.
Sixty infants in whom clinical symptoms suspected of cytomegalovirus (CMV)
infection were studied. CMV infection was found in 50% of the subjects.
The diagnosis was based on studies of specific antibodies and isolation of
the virus from urine and/or throat swabs. In most of the children the
examinations were repeated several times, and clinical observations
continued for 1 to 42 months (avg. 18 months). IgM-class antibodies were
detected in 26 children and in 18 the virus was isolated. In 3 infants,
isolation of CMV virus was the only evidence of active infection.
Persisting viruria (avg. 11 months) and long-term presence of Ig G
antibodies, even to 44th month of life were also observed. Congenital
infection was diagnosed in 4 infants; the remaining ones acquired the
infection during the perinatal period or later. In 7 cases transfused
blood cannot be excluded as the source of infection. The clinical symptoms
manifested in infected and non-infected children were similar. There was
a statistically significant increase in the occurrence of hepatomegaly,
splenomegaly, hyperbiliru-binemia and diarrhoea in infected children.
Congenital abnormalities were found in 10 infected children, including 4
cases of congenital cytomegaly.
PMID: 8525003, UI: 96106106
3. Taylor-Wiedeman J et al. Polymorphonuclear cells are not sites of
persistence of human cytomegalovirus in healthy individuals. Journal of
General Virology. 74 ( Pt 2):265-8, 1993 Feb.
ab: Polymorphonuclear leukocytes (PMNL) have been shown to harbour
human cytomegalovirus (HCMV) in viraemic patients, but to date PMNL of
asymptomatic healthy subjects have not been examined directly to determine
whether this is a normal site of HCMV persistence. Using the polymerase
chain reaction (PCR), paired DNA samples prepared from adherent peripheral
blood mononuclear cells (PBMC), which are known to be a site of
persistence of HCMV, and PMNL of 10 healthy adults were analysed. All of
seven individuals who were HCMV seropositive, and one of three who were
seronegative gave a reproducible signal for HCMV DNA in their adherent
PBMC, whereas none of the paired PMNL DNA samples gave a positive result.
The remaining two seronegative subjects showed no HCMV DNA in either the
PBMC or PMNL samples. In every case where PCR for HCMV was negative, PCR
amplification of a control human gene was used to show there was no
inability to amplify the DNA. We conclude that within the leukocyte
population of normal asymptomatic HCMV carriers, PMNL do not appear to
harbour persistent HCMV whereas adherent PBMC in the same subjects are a
site of persistence.

Goldberg, M. Frontal and Temporal Lobe Dysfunction in autism and Other Related
Disorders: ADHD and OCD. Alasbimn Journal1(4): July 1999.
SUMMARY
Autism, Pervasive Development Disorder (PDD), Attention Deficit Hyperactive
Disorder (ADHD), and Obsessive and Compulsive Disorder (OCD) involve significant
frontal and temporal lobe dysfunction. This conclusion is based on NeuroSPECT
work now in progress on children afflicted with these disorders. We have been
using NeuroSPECT to image cerebral abnormalities of perfusion/function in
Autism, ADHD, OCD, and other neuro-cognitive disorders.
With the increased focus and presentation of children labeled Autistic Syndrome
/ PDD, has come a greater need to understand and define the dysfunction in these
children by objective "functional" quantification, now possible with new imaging
technology such as NeuroSPECT.
The children have been evaluated by means of Xe133 for SPECT, expressing the
results three-dimensionally and rCBF quantitatively in ml/min/100g; and
qualitatively by means of Tc-99 HMPAO. The correlation of cerebral perfusion
with brain function has been established, as NeuroSPECT is a useful tool for
cerebral function assessment.
In this review paper, we will discuss our clinical observation and our rCBF
findings for Autism and these related disorders.
The article may be viewed in full at:
http://www.alasbimnjournal.cl/revistas/4/goldberg.htm
You need to register for free!
Elyse

Could you please stop sending mail as I am going on vacation for two
weeks? I will contact you when I would to get back on the mailing
list. Thank you.

Hayney et al's article illustrates a principle wherein an immune-related genetic
glitch
can lead to altered responses against specific pathogens. Having such a "mild"
genetic
glitch would not only be an interesting tidbit for genetics researchers but
would also
suggest the possibility that in some carriers of the specific allele, their
response
when exposed the pathogen would be less obvious outwardly and possibly more
severe
internally.
In Orlando, Roger Burger -- long time colleague of Reed Warren and Alma Maciulis
--
provided a similar example wherein a boy had no obvious signs of strep infection
but
(aside from some newly acquired Tourette's gestures), but who then tested
positive for
strep and was treated, with some alleviation of the Tourette's symptoms.
In that case, a researcher had been studying the boy's brother and called the
attending
physician and recommended that the child be tested for strep.
The physician was reluctant because there were no *obvious* signs. Luckily,
however, the
researcher was adamant and succeeded in having the test performed.
When I see "missing" antibodies titres against vaccinal antigens in immune
panels from
autism-spectrum children, I respect that datum as a *possible* clue and seek
other signs
that the specific missing-antibodies pathogen might have been or might still be
etiologically significant in that child -- especially if the pathogen is known
to be
capable of neurologic sequelae.
My hunch is that, in a small subgroup of autism-spectrum kids, if he or she has
an
impaired immune response against a certain pathogen, then it is likelier to
achieve
enduring presence as a chronic active (seemingly subclinical) infection.
Another mechanism for misleadingly low antibodies is that of early exposure
(fetal,
neonatal, early infancy) -- a phenomenon well documented in cytomegalovirus
lterature
(cites provided later today). Clues to intestinal participation in the
establishing of a
newborn's response to pathogens can be obtained at:
http://www.jorsm.com/~binstock/cd5-iga.htm
I can't help but wonder if autism-spectrum children with illeal measles signs
have the
HLA-DQA1 (or similar) allele whose presence impaired the child's reponse either
to
wild-type measles or to vaccinal measles antigens.
Teresa
Int J Infect Dis 1998 Jan-Mar;2(3):143-6
Relationship of HLA-DQA1 alleles and humoral antibody
following measles vaccination.
Hayney MS, Poland GA, Jacobson RM, Rabe D, Schaid DJ, Jacobsen SJ, Lipsky JJ
Mayo Vaccine Research Group, Clinical Pharmacology Unit, Mayo Clinic and
Foundation,
Rochester, Minnesota 55905, USA.
BACKGROUND: The human leukocyte antigen (HLA)-DQA1 locus is only moderately
polymorphic compared to other HLA class II loci; however, we hypothesized that
these
polymorphisms could be important in determining the humoral antibody response to
measles
vaccine virus.
METHODS: The seroprevalence of measles antibody was determined in 881 school
children
who had been immunized with MMR-II at age approximately 15 months. All subjects
resided
in a geographic area with no circulating measles virus. The IgG antibody levels
were
determined by a measles-specific whole virus enzyme immunoassay (EIA)
(BioWhittaker,
Walkersville, MD). Subjects who were nonresponders (IgG seronegative or
equivocal) (n =
46) and hyperresponders (upper 10th percentile of IgG levels of all subjects) (n
= 64)
were HLA-DQA1 typed using polymerase chain reaction with sequence-specific
primers
(PCR-SSP). The HLA-DQA1 allele frequencies, as well as homozygosity rates, were
compared
between the nonresponders and hyperresponders.
RESULTS: The overall allele frequency distribution of alleles between the
nonresponders and hyperresponders was significantly different (P = 0.05), with
nonresponders having an excess of HLA-DQA1*05 alleles (P = 0.017) and
hyperresponders
having an excess of HLA-DQA1*01 alleles (P = 0. 016). The homozygosity rate
among
nonresponders was significantly higher than among hyperresponders (23.9% vs.
9.4%, P =
0.037).
CONCLUSION: HLA-DQA1 alleles have important associations with the antibody
response to
measles vaccine. Specifically, the carriage of the HLA-DQA1*05 alleles is
associated
with nonresponse and that of HLA-DQA1*01 alleles with hyperresponse. In
addition,
HLA-DQA1 homozygosity is significantly associated with poor antibody response to
measles
vaccine.
PMID: 9531660, UI: 98246592

I thought I might also add that the Lindamood-Bell program might be worth
looking
at.
My daughter could "do" phonics exercises, but had a phonemic awareness problem.
After I took her out of school for 8 weeks and enrolled her into an intensive
clinic,
5 days a week, 4 hours per day, she could decode words on the 11th grade level.
Funny, when she returned to school, and I had gone over math & science etc, at
home with her, and on the daily 4 hour road trip back & forth to Nashville via
cassette tapes of the lessons, she was not only NOT behind her class, but ahead.
Makes you wonder doesn't it ?... The ADD program and the
Visualizing/Verbalizing
program (V/V) are great. Don't know where any of you are located, but I have a
good
referral in the Nashville area now. Hope all goes well.
Paula

Sandy,
Thanks for the information. I've been sharing the
info. Hopefully if parents see enough info like
this, they might finally decide that they should
have their child looked at from a different
approach, medical.
Cheryl

Glad to read this article since our speech pathologist is recommending we try
this program with our son as soon as he is able. We are going to try the
demo programs first to see if he is at a level to get a high enough accuracy
and if so, see if he will hold the attention span needed for the length of
time they need to spend at the computer. We will let you know how it goes.
Has anyone else tried FastForWord or a program called Earobics which is also
supposed to help with auditory processing. If so, what were your results and
your opinion of the programs? Also, zoo-phonics in the CD Rom version was
recommended to us as a way to get phonics introduced and get our son a little
ahead since he is likely to be high risk when he starts learning to read.
Any feedback on these programs would be appreciated.
Nick's Mom
Janie

I found this interesting article on WebMD
http://my.webmd.com/news/523387
It talks about incidence of autism in families with autoimmune
problems.

Hi all,
I just got the catalog from future horizons on books they have for
autism and aperger's. I would like to know if anyone has looked at the
book "autism-p.d.d.-More creative ideas" (From age 8 to early adulthood)
by Janice Adams. It says it is programs and exercises for the older
student or adult with autism. Ms. Adams offers ideas on social skills,
friendships, sexuality, employment, transition and other areas important
to this age group. its $29.95. My JJ is 11 and I would like to know if
anyone thinks this is a good book. Thanks a lot.
Lois (mom to JJ bug)

Hello to my fellow NIDS groupers. I get so many e-mails from different
groups that I might skim the first few lines and then, if it doesn't grab my
attention, I delete it. However, I'm writing to you all to very strongly
encourage you to read the "Heal Thyself-dot-com: Salon Article" FEAT
recently posted. It so accurately reflects feelings that I have about
alleged/proposed treatments for autism, and I hope that anyone else out
there with this scared feeling in the pit of their stomach will find the
same comforting feeling of "finally--someone says how I feel."

Hi, everybody, and thanks a million to Lois for posting the web site
http://www.oberlin.edu/~bmislin/cp/faq.htm
It is certainly fascinating. You deserve an extra dessert tonight, Lois!
Missy
Princess Shelby's Mommy

Josiane,
Melatonin is available OTC in the US, as it is classified as a "dietary
supplement" and not as a drug. My personal experience of taking it every night
for a couple of years is that it is both safe and very effective; I sleep deeply
and wake feeling refreshed in a way I have not since adolescence. Before I
started taking it I researched it and found that the US military tested it
extensively in the 1950s and found that it caused no permanent ill effects even
in extremely high doses.
There are a number of Internet pharmacies based in the US. Here is one that
says it ships internationally (many do not):
http://www.prices-power.com/fax.htm
Good luck.
Mark Lumsden
mailto:marklumsden@...
http://www.geocities.com/ResearchTriangle/Lab/7253/
josianeherben/43:56 AM
Please respond to NIDS@onelist.com
To: NIDS@onelist.com
cc: (bcc: Mark Lumsden/Raleigh/IBM)
Subject: [NIDS] melatonin
From: josiane herben <josianeherben@...
The nights with our little girl are becoming terrible. I understand that
melatonin is being used by some of you to help these problems. However,
melatonin is not available here in Belgium. So could someone please answer
these questions :
a/ is melatonin available "over the counter" in the U.S. ?
b/ could it be post ordered ? Where ?
c/ is it effective ?
d/ is it save ? are there any side effects ?
Thank you.
Josiane, Marjolein's mother.

From the Autism Resource Konnection to anyone involved in the
"Hear~their~Silence" rally in D.C. April 8, 2000 for Autism Awareness....
GOOD AFTERNOON RALLY PARENTS!!!!!!
As a result of private posts to me asking about copying the donation letter
file and mailing out your own donation letters, the board has decided to do
just that!!
Anyway you can get your donation letters out, please do it!!! If you want
me to do it for you if you have no extra time, tell me. I'll be glad to
help. We need to be getting some donation money in to front costs for
T-shirts and all the extra's for the rally!!
I have the file in Microsoft Word. Send me your desire to have it, and it
will be beamed up to you!!!
PLEASE DO NOT CHANGE THE ARK LETTERHEAD, DATE OF THE RALLY (DUH!!!), OR THE
NAME OF THE RALLY. PLEASE PLEASE PLEASE DO NOT CHANGE THOSE THINGS IN THE
LETTER. YOU MAY PERSONALIZE YOURS FOR FAMILY AND FRIENDS AND CO-WORKERS,
ETC....
WE ARE ASKING THAT ALL CORPORATE DONATION LETTER REQUESTS STILL GO THROUGH
ME FOR THE DATABASE AND RECORDKEEPING. SEND ME YOUR CORPORATE DONATION
LETTER REQUESTS AND I WILL GET THOSE TYPED UP AND ENTERED IN THE DATABASE,
then mailed back to you to sign.
Before you mail your donation letters out, let me know how many
donation/remittance envelopes you need to include in the letters you mail
out. I have some printed up with ARK's address, and tax information for
non-profit status, and other information about ARK. Please please please
tell me how many to send to you when you request the file to copy.
Carol F asked me to post this, as she is out of town. Her son's VBS picks a
children's charity to donate the proceeds to from the money collected from
the kids during the week. She asked if they would use the ARK as their
charity, and to make a long story short - THEY ARE!!!! IT NEVER HURTS TO
ASK!!! Also, in the same town where Carol lives, a woman on a mission,
received 2 MILLION DOLLARS FOR AN AUTISM GROUP IN THAT CITY!!! ONE WOMAN!
The complete story is on the secretin-talk post for more detailed
information. ONE PERSON CAN MAKE A DIFFERENCE - ASK ASK ASK, ALL THEY CAN
SAY IS NO NO NO!!!!! Also, I believe that the same woman asked for a
grant for a documentary project on autism, and received 15,000 more dollars
than she applied for! Again, seek out Kenivan for more details on that.
One mother asked the local paper to do a story about her Autistic child, and
they finally did!!! I will post more details Wednesday about what website
to look up to read the article. Carol was misquoted on a couple of issues,
and they didn't print all she hoped they would, but it was a story on
Autism, and it was in the local paper, and it will draw awareness toward our
goal!!!!! Hound your local media!!! ASK ASK ASK, AND EVENTUALLY THEY
WILL GET SICK OF US AND SAY YES YES YES!!!!!
Have a great week!!!! Get those donation letters out!!!!
Michelle Guppy
tguppy@...
All requests for flyers that I have received up to yesterday will be mailed
out tonight.
Keep em coming!

The nights with our little girl are becoming terrible. I understand that
melatonin is being used by some of you to help these problems. However,
melatonin is not available here in Belgium. So could someone please answer
these questions :
a/ is melatonin available "over the counter" in the U.S. ?
b/ could it be post ordered ? Where ?
c/ is it effective ?
d/ is it save ? are there any side effects ?
Thank you.
Josiane, Marjolein's mother.

I just got this off of another site!!! It really looks interresting!!!!!
http://www.oberlin.edu/~bmislin/cp/faq.htm
Lois (JJs mom)

hello Marie,
I am Josiane. I'm rather new on the list myself, so I don't feel I'm the
right person to say "welcome" to you ! I just wanted to tell you that I
really found some useful information on the list and I do hope you will find
it too. I wish you a lot of strength and courage in all the problems you
are facing. We are parents of a three year old girl, mentally disabled and
autistic. The future doesn't look bright for her, but we will never stop
fighting. Greetings, Josiane.

Hello,
I just joined the list and have been eagerly working
my way through the archives.I have rheumatoid arthritis
and MS. My oldest son (age15)has Aspergers, epilepsy, ADHD and
learning disabilities. My second son (age14) has
Down syndrome and a severe heat intolerance. My
daughter is now ill with what looks like chronic
fatigue and/or orthostatic intolerance. At the same
time she became ill, she developed a severe
allergy to milk.I've searched for research on possible
connections to all this and I'm looking forward to
sharing and learning with others on the list.
Marie

Hi Listmates,
Could anyone that knows please let me know if Dr bradsreet is doing
infustions or transdermal with his son and how often is he doing it?
Thank you very much,
Lois (JJs mom)

cheryl wrote about pestidies and their connection to:
include brain cancer,neurological disorders, immune
system dysfunction,asthma, allergies, infertility,
child behavioral disorders including learning
disabilities,mental retardation, hyperactivity,
and ADD.
=======
i read this list as i have cfids and mcs, because i
noted that dr. klimas, who my internist respects, was
working with dr. goldberg on mat. i learn from y'all
and my chronic immune activation started as an adult.
i mentioned earlier using cromolyn sodium to
cut down histamine release, i was unclear what
i used it for, it was not for food, i follow
a fanatic diet without gluten etc.. instead
cromolyn sodium seems to calm down a bit the
chemical exposures when i get inadvertently hit.
regarding pesticides: they are my worst symptom
trigger, causing swollen glands, killer sore,
throat, ear pain, exhaustion and total brain fog.
herbicides pack an extra punch, throwing in
diarrhea and migraine as well. total torture.
whether this causes a problem or helps perpetuate
it, varies of course by individual, but i think it
makes sense to avoid pesticides, including herbicides,
for those of us with besieged immune systems.
I attended the LDA conference on endocrine
disruption on february 24, 1999 in atlanta.
i learned how endocrine disruption has major
effects on brain development in the fetus,
in part by messing up the thyroid. a tape
was made by vanderbilt university and my
env. group, and it is available from my
env. group for $30 for 6 hours of talks.
contact me if you are interested.
please avoid pesticides because they
are biocides and affect humans too!
nancy mcfadden, nashville tennessee
mcs/cfids 70% recovered,
looking for the last 30%

Nancy, Maura, et al,
Yes, I've been perusing Jonty's med records. With Maura's consent, a summary of
my
initial evaluation has been posted http://www.jorsm.com/~binstock/jonty.htm
Two other kids' critiques are presented thus far:
http://www.jorsm.com/~binstock/ebv-case.htm
http://www.jorsm.com/~binstock/mike-1.htm
noting that each case is very different.
In response to your question about HLA genes as predisposing factors:
One parent who contributes to the autism list has an autism-spectrum child and a
neurotypical child. One of them has the null allele for complement C4b, which
Reed
Warren, Roger Berger, and Alma Maciulis have shown to be statistically
associated with
autism. Importantly, many people with null alleles of C4b do not progress into
the
autism spectrum, and many autism-spectrum kids do not have null alleles of C4b.
The C4b
gene leads to proteins involved with complement and immune function. Presumably,
the
link to autism is via infections, because having a null allele of C4b means that
the
person tends to have impaired response to various infections. In the
aforementioned
family, the neurotypical child has the null allele and the autism-spectrum child
does
not.
Association studies of large groups of people oftentimes can't tell us much
about
specific individuals.
Diabetes provides an example. The search for genes whose mutations are capable
of
inducing diabetes has found more than 12 such genes (and I stopped collecting
those
articles two years ago, ie, the number is probably higher). However, studies
within the
last several years have strongly implicated Coxsackie virus in many cases of
IDDM, and I
recently posted a host of citations into the autism-list about this.
When I look at med history and lab data for kids like Jonty, I don't pay much
attention
to HLA haplotypes, with the exception that of looking at the complement levels
data,
which (if low) can represent a null-allele of C4b (or other, rarer genetic
glitches)
and/or can mean the complement is nicely activated and being consumed (thus the
low
level).
For instance, some parents approach me with lots of data collected before having
ever
read a single one of my posts. During or after my perusal of their child's med
history
and lab data, I have never been tempted to suggest that the parents purchase HLA
rare-allele haplotype analyses (tho' I have suggested to several that they might
consider contacting the Roger Burger/Reed Warren/Alma Maciulis lab in Utah so as
to help
pin-down low complement levels and possible causes thereof. And I've been known
to
recommend (from my position as a non-MD researcher) to the parents and to the
child's
physicians that they consider other tests as justified by various factors for
which more
than a few citations are usually provided.
Importantly, Warren et al found (i) that null C4b alleles are statistically
associated
with autism, and (ii) that low levels of the protein derived from C4b genes were
associated with autism, noting that individuals can have an OK C4b gene but
still have
low levels of complement.
Bottom line: I find the HLA haplotype studies interesting, and they are
providing
important insights; however, other lab tests can provide far more meaningful
about a
specific child and possibly significant pathogenic presence and/or immune shifts
and
treatments thereof.
Teresa
My most recent analysis and report for an autism-spectrum child can be found at:
http://www.jorsm.com/~binstock/mike-1.htm
(That's the index page to a very thorough report withsubpages)
Mike's lab-data taught me a lot! And later today I hope to post one more subpage
wherein
I list the lab-test data available to me, and delineate how my thinking
progressed from
initial wonderings to a final (albeit initial) focus.
http://www.josrm.com/~binstock/mike-9.htm (later today)

The following citation appears to be a thorough review whose insights will be
important
for parents of autism-spectrum children whose immune-panels indicate extremely
high
elevations of the *various* anti-EBV antibodies that can be measured.
In such children, merely measuring anti-EBV IgM and anti-EBV IgG is not
sufficient.
Additional anti-EBV tests can be more instructive, eg, for certain EBV markers
that
indicate status of the underlying infection.
Importantly, a *few* of the children whose charts I've perused have not only
significant
elevations of anti-EBV titres (including some of the more specific assays) but
also have
immune-cell subset counts reinforcing concern with the underlying EBV infection.
In rare cases, EBV is directly implicated in neurologic deficits,
eg, a citation and discussion in: http://www/jorsm.com/~binstock/ebv-case.htm
If the following citation's article is as good as the abstract, then this
article is a
must read for some of us.
Teresa
Front Biosci 1999 Mar 15;4:D346-71
Epstein-Barr virus immortalization and latency.
Rowe DT
Department of Infectious Diseases and Microbiology, Graduate School of Public
Health,
University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15213, USA.
rowe1+@...
Epstein-Barr virus infects human B lymphocytes. The interaction between the
virus and
these cells has been the subject of investigation for over three decades. Recent
in
vitro and in vivo studies, reviewed here, are revealing the mechanisms by which
EBV
induces and controls proliferation through the expression of six viral nuclear
proteins
and two plasma membrane proteins. This genetic program is referred to as
immortalization
and it is suggested that the purpose of immortalization is to use the innate
proliferative potential of B cells to inflate the numbers of infected cells
prior to
virus production and cell lysis. Latency, on the other hand, has only been
detected in
situ in latently infected humans. It is characterized by the presence of very
low
numbers of viral episomes that appear to express the RNA for only one protein
(Latent
Membrane Protein 2) in B cells that bear the markers of a non-activated resting
memory
subset. Two models are proposed for the mechanism that establishes this state.
The
differences between immortalization and latency are highlighted in this review
and it is
suggested that many of the functions currently attributed to latency are
actually
features of immortalization. An appreciation of this distinction may assist the
discussion of the nature of the interaction between the virus and the host in
EBV-associated lymphoproliferative diseases and tumors.
Publication Types: Review Review, tutorial
PMID: 10077545, UI: 99179070

A very interesting web address came across another
group I belong to. I have always felt that all
the pesticides I was exposed to at work plus the
fact that my house was tented and then I also
had my house fumigated, played a role in the
development of my autoimmunity. My nids son was
only six weeks old when I had my house fumigated.
The information at this site was compiled by
Wayne Sinclair,M.D.,Allergy,Asthma & Immunology
Vero Beach F. Richard Pressinger,M.Ed.,Tampa Fl
The site provides links to research finding health
disorders resulting from exposure to common
chemicals and pesticides. All research was
conducted by major medical universities and
research agencies. Illnesses now identified
include brain cancer,neurological disorders,
immune system dysfunction,asthma, allergies,
infertility,child behavioral disorders including
learning disabilities,mental retardation,
hyperactivity, and ADD.
http://www.chem-tox.com/
Cheryl

http://news.excite.com/news/r/990624/17/health-kid15

Please unsubscribe me. Thanks.

I recently evaluated medical history and laboratory reports for an
autism-spectrum child whose data led me into the literatures of
Klebsiella pneumoniae and hemolytic Escherichia coli.
Preparing a report for the parents led to some fine insights, which
are shared on a series of webpages, with the new reports primary
index page being http:www.jorsm.com/~binstock/mike-1.htm
The report illustrates the interplay between data from various
laboratories (eg, the Great Smokies data & a thorough immune
panel). In this particular case, the Great Smokies data appears to
have been the most specifically significant, even as interpreting
that data was augmented by a Fudenberg panel, WBC/RBC analyses, and
other tests.
Also, the new report outlines and offers citations supporting a way
that intestinal colonization, increased permeability, and bacterial
translocation might actually induce vascular and astrocytic
inflammation along the blood brain barrier, thereby inducing
hypoperfusion to ajoining neurons and hypofunction in those neurons
and also in neural circuits connected therewith.
Whew! Perusing the child's data and related literature taught me
much, and I'd like to thank the parents and their son Michael for
helping all of us acquire an additional glimpse (one case study at
a time) into biological aspects in *specific* autism-spectrum
children.
Importantly, this case study focused upon data quite different from
the other two case studies already presented on my website (1).
The most basic two webpages in the new report are:
http://www.jorsm.com/~binstock/mike-1.htm
http://www.jorsm.com/~binstock/mike-2.htm
The subsequent pages are very full of citations, so if a person
wants a summary of the entire new findings, I suggest printing the
first several pages of each:
http://www.jorsm.com/~binstock/mike-1.htm print all
http://www.jorsm.com/~binstock/mike-2.htm print all
http://www.jorsm.com/~binstock/mike-3.htm print 1st several pages